Wang Zheng

Divergent effects of ketamine and psilocybin on EEG power spectral density in a mismatch negativity paradigm

Psychopharmacology November 5, 2025 Milad Soltanzadeh, Wang Zheng, Shona G. Allohverdi et al. 1 citation

RationaleKetamine and psilocybin have demonstrated therapeutic potential for mental disorders, including major depressive disorder, yet they engage distinct mechanisms of action. Ketamine, a dissociative hallucinogen, acts by blocking N-methyl-D-aspartate receptors (NMDAR), whereas psilocybin primarily targets serotonin receptors. These divergent mechanisms are reflected in their...