Differential effects of psilocybin and lisuride on serotonin and dopamine neuronal activity and behavior
Progress in Neuro-psychopharmacology and Biological Psychiatry October 1, 2025 Brandon Richardson, Antonio Inserra, Michael Pileggi et al. 2 citations
Psilocybin and lisuride are 5-HT2A receptor agonists, but only psilocybin elicits the head twitch response (HTR) in rodents, a behavior commonly used as a proxy for hallucinogenic activity. This study aimed to compare their effects on serotonin (5-HT) and dopamine (DA) neuronal activity, as well as related behavioral outcomes, to elucidate the mechanisms underlying their divergent effects....