Mescaline‐induced head‐twitches in the rat: An in vivo method to evaluate serotonin S2 antagonists
Drug Development Research 1983 C. J. E. Niemegeers, Françis C. Colpaert, J.e. Leysen et al. 58 citations
Abstract An intravenous dose of 20.0 mg/kg of mescaline induced a reproducible head‐twitch response in rats. Drugs with very different pharmacological activities were tested for potential inhibition of this response. Among these drugs were a large number of serotonin antagonists, including several members of the recently described selective S 2 antagonists of which ketanserin (a potent vascular...