MDMA pretreatment leads to mild chronic unpredictable stress-induced impairments in spatial learning.
Behavioral Neuroscience October 1, 2009 Jacobi I. Cunningham, Jamie Raudensky, John Tonkiss et al. 27 citations
3,4-Methylenedioxymethamphetamine (MDMA) is a drug of abuse worldwide and a selective serotonin (5-HT) neurotoxin. An important factor in the risk of drug abuse and relapse is stress. Although multiple parallels exist between MDMA abuse and stress, including effects on 5-HTergic neurotransmission, few studies have investigated the consequences of combined exposure to MDMA and chronic stress....