Stereoselective pharmacokinetics of 3,4‐methylenedioxymethamphetamine in the rat
Chirality 1990 Robert L. Fitzgerald, Robert V. Blanke, Alphonse Poklis 50 citations
Abstract Studies to characterize the pharmacokinetics of the enantiomers of MDMA were conducted in rats using the iliac arterial cannulation. Two routes of administration, intravenous and subcutaneous, were evaluated at two dose levels for each route [20 and 40 mg/kg (±)‐MDMA for subcutaneous, 10 and 20 mg/kg (±)‐MDMA for intravenous administrations]. The average half‐life (±SD) for all dosing...