Progress in neuro-psychopharmacology & biological psychiatry
October 17, 2026
Fionnghuala L J James, Sayed K Ahamed, Cheng-I Yang et al.
Traumatic memories that are resistant to modification or extinction are a characteristic feature of post-traumatic stress disorder (PTSD). The process of fear memory reconsolidation has been identified as a potential therapeutic target for the treatment of PTSD. Ketamine, an NMDA receptor antagonist with dissociative properties, has been identified as a drug with high therapeutic potential for...
Pharmacology & Therapeutics
November 1, 2022
Sanket B Raut, Padmaja A Marathe, Liza Van Eijk et al.
62 citations
Post-traumatic stress disorder (PTSD), characterized by abnormally persistent and distressing memories, is a chronic debilitating condition in need of new treatment options. Current treatment guidelines recommend psychotherapy as first line management with only two drugs, sertraline and paroxetine, approved by U.S. Food and Drug Administration (FDA) for treatment of PTSD. These drugs have...
Developmental Neuroscience
2014
Juan J. Canales, Agueda Ferrer-Donato
Recreational drug use among pregnant women is a source of concern due to potential harmful effects of drug exposure on prenatal and infant development. The simultaneous abuse of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] and alcohol is prevalent among young adults, including young expectant mothers. Here, we used a rat model to study the potential risks associated with exposure to...
Addiction Biology
October 1, 2010
Vicente Hernández‐rabaza, Graciela Navarro‐mora, Clara Velázquez-sánchez et al.
40 citations
ABSTRACT Recent trend assessments of drug consumption reveal an increase in the simultaneous use of several drugs at raves, clubs and college settings among youngsters and young adults. We studied in adolescent rats the effects of repeated exposure to cocaine and 3,4‐methylenedioxymethanphetamine (MDMA, ecstasy), given alone or in combination with alcohol, on memory performance, adult...