The rewarding properties of MDMA are preserved in mice lacking µ‐opioid receptors
European Journal of Neuroscience July 15, 2004 Patricia Robledo, Victoria Mendizábal, Jordi Ortuño et al. 40 citations
Abstract The involvement of µ‐opioid receptors in the rewarding properties of MDMA was explored in µ‐opioid receptor knockout mice using the conditioning place preference paradigm. The associated release of dopamine in the nucleus accumbens was investigated by in vivo microdialysis. A significant rewarding effect of MDMA (10 mg/kg, i.p.) was observed in both wild‐type and µ‐opioid receptor...