Katja Bakker

2 papers in the library · 173 citations · publishing 2011-2012

Papers

Effects of Acute MDMA Intoxication on Mood and Impulsivity: Role of the 5-HT2 and 5-HT1 Receptors

PLoS One July 10, 2012 Janelle H. P. van Wel, Kim P. C. Kuypers, Eef L. Theunissen et al. 121 citations

MDMA increases both positive moods (vigor, arousal, friendliness, elation) and negative moods (anxiety, confusion) while also slowing reaction times on impulsivity tasks, indicating greater impulse control. Blocking 5-HT(2) receptors with ketanserin prevented the positive mood effects but not the negative mood or impulsivity changes. Blocking 5-HT(1) receptors with pindolol had no effect on any MDMA-related mood or impulse measures. Thus, 5-HT(2) receptors are specifically involved in MDMA's positive mood enhancement, while 5-HT(1) receptors do not appear to play a role in these effects.

DOI: 10.1371/journal.pone.0040187 MDMA Ecstasy Impulsivity Ketanserin +9

Blockade of 5-HT2 Receptor Selectively Prevents MDMA-Induced Verbal Memory Impairment

Neuropsychopharmacology May 11, 2011 Janelle H. P. van Wel, Kim P. C. Kuypers, Eef L. Theunissen et al. 52 citations

Blocking the 5-HT(2A) receptor with ketanserin prevented MDMA-induced impairment on a word-learning task, but not on spatial or prospective memory tasks. Blocking the 5-HT(1A) receptor with pindolol had no effect on any memory task. MDMA alone significantly impaired performance in all three memory tasks. The findings indicate that MDMA-induced verbal memory impairment is mediated by 5-HT(2A) receptor stimulation.

DOI: 10.1038/npp.2011.80 Full text MDMA Blockade Psychology Memory impairment +2