Implications of mechanism-based inhibition of CYP2D6 for the pharmacokinetics and toxicity of MDMA
Journal of Psychopharmacology May 20, 2006 Jiansong Yang, Masoud Jamei, Amir Heydari et al. 89 citations
The aim of this study was to model the in vivo kinetic consequences of mechanism-based inhibition (MBI) of CYP2D6 by 3,4 methylenedioxymethamphetamine (MDMA, ecstasy). A model with physiologically-based components of drug metabolism was developed, taking account of change in the hepatic content of active CYP2D6 due to MBI by MDMA. Based on the in vitro information, plasma concentration time...