Persistent MDMA‐induced dopaminergic neurotoxicity in the striatum and substantia nigra of mice
Journal of Neurochemistry September 24, 2008 Noelia Granado, Esther O’shea, Jordi Bové et al. 112 citations
Abstract Acute administration of repeated doses of 3,4‐methylenedioxymethamphetamine (MDMA, ecstasy) dramatically reduces striatal dopamine (DA) content, tyrosine hydroxylase (TH), and DA transporter‐immunoreactivity in mice. In this study, we show for the first time the spatiotemporal pattern of dopaminergic damage and related molecular events produced by MDMA administration in mice. Our...