Pharmacokinetic and pharmacodynamic effects of methylphenidate and MDMA administered alone or in combination
The International Journal of Neuropsychopharmacology October 8, 2013 Cédric M. Hysek, Linda D. Simmler, Nathalie Schillinger et al. 125 citations
Methylphenidate and 3,4-methylenedioxymethamphetamine (MDMA, 'ecstasy') are widely misused psychoactive drugs. Methylphenidate increases brain dopamine and norepinephrine levels by blocking the presynaptic reuptake transporters. MDMA releases serotonin, dopamine and norepinephrine through the same transporters. Pharmacodynamic interactions of methylphenidate and MDMA are likely. This study...