Opioid-free anaesthesia to reduce postoperative nausea and vomiting after lower extremity wound surgery: a randomised double-blind crossover trial.
Annals of medicine December 1, 2025 Ya-Juan Zhu, Yao-Yu Ying, Hua-Yue Liu et al. 7 citations
Postoperative nausea and vomiting (PONV) are common complications after surgery. Opioid use is a significant risk factor. We utilised a crossover design to test this hypothesis in the same individuals that opioid-free anaesthesia (OFA) compared with opioid-inclusive anaesthesia reduces PONV. This randomised double-blind crossover trial included adult patients undergoing two surgical procedures...
DOI: 10.1080/07853890.2025.2517819 (opens in new tab)
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Lower extremity
Opioid-free anaesthesia
Wound surgery
Anesthesia anaesthesia
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