Omar B Sanchez-Reyes

Molecular insights into GPCR mechanisms for drugs of abuse.

Journal of Biological Chemistry September 1, 2023 Omar B Sanchez-Reyes, Gregory Zilberg, John D. Mccorvy et al. 10 citations

Substance abuse is on the rise, and while many people may use illicit drugs mainly due to their rewarding effects, their societal impact can range from severe, as is the case for opioids, to promising, as is the case for psychedelics. Common with all these drugs' mechanisms of action are G protein-coupled receptors (GPCRs), which lie at the center of how these drugs mediate inebriation,...