Ayahuasca is an ancient psychoactive ethnobotanical medicine tea used by indigenous S. American tribes as a religious sacrament. It is made from the vine of B. caapi and the leaves of P. viridis and represents an ancient yet 'novel' short and long-term serotonin agonist. Here we present preclinical pharmacognosy data as an early step towards phase I and II clinical trials of ayahuasca in...