β-carboline-independent antidepressant-like effect of the standardized extract of the barks of Mimosa tenuiflora (Willd) Poir. occurs via 5-HT2A/2C receptors in mice
Journal of Psychopharmacology June 20, 2022 Luiz Antonio Miranda de Souza Duarte Filho, Isabela Araújo E Amariz, Rodolfo Hideki Vicente Nishimura et al. 12 citations
A standardized extract of Mimosa tenuiflora (SEMT), the plant used to prepare jurema wine, shows antidepressant-like effects in mice. The extract contains 24.74 ± 0.8 mg/g of N,N-dimethyltryptamine (DMT) and also yuremamine. In the tail suspension and forced swim tests, SEMT reduced immobility, indicating antidepressant-like activity, and this effect did not require harmine, a β-carboline. A sub-dose combination with ketamine also reduced immobility. SEMT enhanced head twitch behavior induced by 5-HTP, and ketanserin blocked its antidepressant-like effect, suggesting the effect involves activation of 5-HT2A/2C receptors.