Discriminative Stimulus Effects of Substituted Tryptamines in Rats
ACS Pharmacology & Translational Science December 29, 2020 Michael B. Gatch, Adam C. Hoch, Theresa M. Carbonaro 13 citations
Novel synthetic compounds have been available for decades as quasi-legal alternatives to controlled substances. The hallucinogen-like effects of eight novel substituted tryptamines were evaluated to determine their potential abuse liability. Male Sprague-Dawley rats were trained to discriminate 2,5-dimethoxy-4-methylamphetamine (DOM, 0.5 mg/kg, i.p., 30 min) from saline....