Metabolic Brain Disease
February 27, 2020
Camila Schoueri Colaço, Stefany Sousa Alves, Luciana Marangni Nolli et al.
56 citations
Ayahuasca is a hallucinogenic beverage that affects the serotonergic system and have therapeutic potential for many diseases and disorders, including depression and drug addiction. The objectives of this study were to evaluate the potential toxic effects of ayahuasca on rats after chronic exposure, and the levels of monoamines, their metabolites and the brain-derived neurotrophic factor (BDNF)...
Alcohol
November 4, 2019
Luciana Marangni Nolli, Danilo Gustavo Rodrigues de Oliveira, Stefany Sousa Alves et al.
28 citations
Ayahuasca is a hallucinogenic infusion used in religious rituals that has serotoninergic properties and may be a potential therapeutic option for drug addiction. In this study, Wistar rats had intermittent access to ethanol for 8 weeks, receiving water (control), naltrexone (NTX, 2 mg/kg body weight [bw] intraperitoneally [i.p.]) or ayahuasca (Aya) at 0.5x, 1x, or 2x the ritual dose in the...
Chemico-Biological Interactions
August 4, 2018
Thayres S. Andrade, Rhaul Oliveira, Muriel Lopes Da Silva et al.
31 citations
Ayahuasca is a psychoactive concoction prepared from the plants Banisteriopsis caapi and Psychotria viridis which are used ancestrally by Amazonian Indian populations and more recently, by Christian religious groups in Brazil and other countries. The aims of the present study were to identify the effects of ayahuasca on zebrafish embryo development and neurobehavior. Toxicity and developmental...
Reproductive Toxicology
March 6, 2018
Luciana Gueiros Da Motta, Juliana Alves de Morais, Ana Carolina A.m. Tavares et al.
27 citations
Rats were treated orally with ayahuasca (AYA) on gestation days (GD) 6-20 at doses corresponding to one-(1X) to eight-fold (8X) the average dose taken by a human adult in a religious ritual, and the pregnancy outcome evaluated on GD21. Rats treated with 4X and 8X doses died during the treatment period (44 and 52%), and those that survived showed kidney injury. Rats surviving the 8X dose showed...
Revista Brasileira de Farmacognosia
March 9, 2017
Alana de Fátima Andrade Santos, Ana Luiza Sarkis Vieira, Aline Pic‐taylor et al.
19 citations
Ayahuasca is a psychoactive beverage used ancestrally by indigenous Amazonian tribes and, more recently, by Christian religions in Brazil and other countries. This study aimed to investigate the reproductive effects of this beverage in male Wistar rats after chronic exposure. The rats were treated by gavage every other day for 70 days at 0 (control), 1, 2, 4 and 8 the dose used in a religious...
Behavioural Processes
June 6, 2015
Aline Pic‐taylor, Luciana Gueiros Da Motta, Juliana Alves de Morais et al.
99 citations
Ayahuasca, a psychoactive beverage used by indigenous and religious groups, is generally prepared by the coction of Psychotria viridis and Banisteriopsis caapi plants containing N,N-dimethyltryptamine (DMT) and β-carboline alkaloids, respectively. To investigate the acute toxicity of ayahuasca, the infusion was administered by gavage to female Wistar rats at doses of 30X and 50X the dose taken...