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Daniel Röshammar

3 papers in the library · 38 citations · publishing 2022-2023

Papers

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Optimized infusion rates for N,N-dimethyltryptamine to achieve a target psychedelic intensity based on a modeling and simulation framework.

CPT: Pharmacometrics & Systems Pharmacology October 1, 2023 Emma Eckernäs, Jeroen Koomen, Christopher Timmermann et al. 1 citation

N,N-dimethyltryptamine (DMT) is a psychedelic compound that is being studied as a therapeutic option in various psychiatric disorders. Due to its short half-life, continuous infusion of DMT has been proposed to extend the psychedelic experience and potential therapeutic effects. The primary aim of this work was to design an infusion protocol for DMT based on a desired level of psychedelic...

DOI: 10.1002/psp4.13037 (opens in new tab) Full text (opens in new tab) Psychedelic-therapy DMT-Research Clinical-protocols Pharmacology +1

N,N‐dimethyltryptamine affects electroencephalography response in a concentration‐dependent manner—A pharmacokinetic/pharmacodynamic analysis

CPT: Pharmacometrics & Systems Pharmacology February 10, 2023 Emma Eckernäs, Christopher Timmermann, Robin Carhart-Harris et al. 15 citations

Abstract N,N‐dimethyltryptamine (DMT) is a psychedelic substance and is being used as a research tool in investigations of the neurobiology behind the human consciousness using different brain imaging techniques. The effects of psychedelics have commonly been studied using electroencephalography (EEG) and have been shown to produce suppression of alpha power and increase in signal diversity....

DOI: 10.1002/psp4.12933 (opens in new tab) DMT Psychedelics Brain waves Consciousness research

Population pharmacokinetic/pharmacodynamic modeling of the psychedelic experience induced by N,N‐dimethyltryptamine – Implications for dose considerations

Clinical and Translational Science September 11, 2022 Emma Eckernäs, Christopher Timmermann, Daniel Röshammar et al. 22 citations

Abstract N,N‐dimethyltryptamine (DMT) is a psychedelic compound that is believed to have potential as a therapeutic option in several psychiatric disorders. The number of clinical investigations with DMT is increasing. However, very little is known about the pharmacokinetic properties of DMT as well as any relationship between its exposure and effects. This study aimed to characterize...

DOI: 10.1111/cts.13410 (opens in new tab) Pharmacology Nonmem Pharmacokinetics Pharmacodynamics +2