October 14, 2026Dayne Rayford, Shivani Dayal, Kosu Boudreau et al.
preprint
Background and aimsPsilocybin can induce profound alterations in perception, emotion and self-referential processing. These changes are often accompanied by increased feelings of interpersonal connection, found via both psychometric survey data and anecdotally collected qualitative data. Despite recent increases in psychedelic research and treatment, most clinical trials have been performed in...
May 1, 2025Jessi Humphreys, Lou Lukas, Yvan Beaussant et al.
Abstract Psilocybin, a naturally occurring psychoactive compound found in more than 200 mushroom species, has an enduring history of use in sacred rituals of Indigenous healers worldwide. With selective serotonin receptor binding, activation of the serotonergic neurological system enables psilocybin to potentiate neuroplasticity, enabling individuals to engage in meaning-making from psychedelic...
Psychedelic-assisted therapy (PAT) has re-emerged as a promising intervention for addressing mental health conditions and existential concerns. Despite growing enthusiasm, PAT may be difficult to integrate into mainstream health systems. The rich sacramental traditions of psychedelics, their centering of the human experience, proposed substrates of action, context-dependent outcomes, and highly...