Antidepressants enter cells, organelles, and membranes.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 2024 Zack Blumenfeld, Kallol Bera, Eero Castrén et al. 10 citations
We begin by summarizing several examples of antidepressants whose therapeutic actions begin when they encounter their targets in the cytoplasm or in the lumen of an organelle. These actions contrast with the prevailing view that most neuropharmacological actions begin when drugs engage their therapeutic targets at extracellular binding sites of plasma membrane targets-ion channels, receptors,...