Ketamine Produces Antidepressant Effects by Inhibiting Histone Deacetylases and Upregulating Hippocampal Brain-Derived Neurotrophic Factor Levels in a Diisopropyl Fluorophosphate-Based Rat Model of Gulf War Illness.
Journal of Pharmacology and Experimental Therapeutics January 17, 2024 Ana Ribeiro-Davis, Dalia Y Al Saeedy, Fay M Jahr et al. 10 citations
Approximately one-third of Gulf War veterans suffer from Gulf War Illness (GWI), which encompasses mood disorders and depressive symptoms. Deployment-related exposure to organophosphate compounds has been associated with GWI development. Epigenetic modifications have been reported in GWI veterans. We previously showed that epigenetic histone dysregulations were associated with decreased...
DOI: 10.1124/jpet.123.001824 (opens in new tab)
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Ketamine therapy
Neuroscience research
Veterans health
Depression treatment
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