Psychedelics elicit their effects by 5-HT2A receptor-mediated Gi signalling.
Nature January 28, 2026 Zheng Xu, Hongshuang Wang, Jingjing Yu et al. 5 citations
Psychedelics are undergoing a renaissance as potential therapy for psychiatric disorders, with more than 200 clinical trials being studied across several countries1-3. However, the precise mechanisms by which these drugs bring about benefits and the potential clinical risks are not yet fully understood. The serotonin 2A receptor (5-HT2AR) was reported to be a Gq-coupled receptor and the primary...