Psilocybin’s effect on human brain synaptic plasticity
Research Square October 10, 2025 Gitte M. Knudsen, Annette Johansen, Pontus Plavén-sigray et al.
Abstract Psychedelics such as psilocybin have been linked to enhanced neuroplasticity and symptom relief in affective disorders, but the neurobiological mechanisms and impact of environmen-tal context remain unclear. Here, we tested whether a single dose of psilocybin alters synap-tic density in healthy individuals and whether setting-dependent subjective experience shapes this effect. Fifteen...