Effective connectivity of the human claustrum: Triple networks, subcortical circuits, and psychedelic modulation
bioRxiv (Cold Spring Harbor Laboratory) September 12, 2025 Navid Shams Masjedi, Adeel Razi preprint
Abstract Decades of cross-species research highlight the claustrums extensive bidirectional connectivity with cortical and subcortical regions, implicating it in higher-order cognitive processes requiring synchronized brain states. Psychedelics may disrupt this synchrony by modulating claustro-cortical signaling, reflected by the dissolution of cortical network signatures. Using spectral...