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Jacob Madsen

4 papers in the library · 261 citations · publishing 2010-2014

Papers

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Serotonin 2A Receptor Agonist Binding in the Human Brain with [11C]Cimbi-36

Journal of Cerebral Blood Flow & Metabolism April 30, 2014 Anders Ettrup, Sofi Da Cunha‐bang, Brenda Mcmahon et al. 106 citations

[ 11 C]Cimbi-36 was recently developed as a selective serotonin 2A (5-HT 2A ) receptor agonist radioligand for positron emission tomography (PET) brain imaging. Such an agonist PET radioligand may provide a novel, and more functional, measure of the serotonergic system and agonist binding is more likely than antagonist binding to reflect 5-HT levels in vivo. Here, we show data from a...

DOI: 10.1038/jcbfm.2014.68 (opens in new tab) Serotonin agonist Human brain 5-HT Receptor Endocrinology +1

In abstinent MDMA users the cortisol awakening response is off-set but associated with prefrontal serotonin transporter binding as in non-users

The International Journal of Neuropsychopharmacology February 14, 2014 Vibe G. Frøkjær, David Erritzøe, Klaus K. Holst et al. 19 citations

Serotonergic signaling is considered critical for an appropriate adaptation to stress. We have previously observed that in healthy volunteers, prefrontal serotonin transporter (SERT) binding is positively associated with hypothalamic-pituitary-adrenal (HPA)-axis output in terms of the cortisol awakening response (CAR). Here, we tested (1) if such a correlation persists in a human model of...

DOI: 10.1017/s1461145714000066 (opens in new tab) Full text (opens in new tab) MDMA Serotonin transporter Clinical psychology Receptor

In Vivo Imaging of Cerebral Serotonin Transporter and Serotonin2A Receptor Binding in 3,4-Methylenedioxymethamphetamine (MDMA or “Ecstasy”) and Hallucinogen Users

Archives of General Psychiatry June 6, 2011 David Erritzøe, Vibe G. Frøkjær, Klaus K. Holst et al. 86 citations

We found evidence that MDMA but not hallucinogen use is associated with changes in the cerebral presynaptic serotonergic transmitter system. Because hallucinogenic drugs primarily have serotonin(2A) receptor agonistic actions, we conclude that the negative association between MDMA use and cerebral SERT binding is mediated through a direct presynaptic MDMA effect rather than by the serotonin(2A)...

DOI: 10.1001/archgenpsychiatry.2011.56 (opens in new tab) Full text (opens in new tab) MDMA Ecstasy Hallucinogen Serotonin transporter +5

Radiosynthesis and Evaluation of 11C-CIMBI-5 as a 5-HT2A Receptor Agonist Radioligand for PET

Journal of Nuclear Medicine October 18, 2010 Anders Ettrup, Mikael Palner, Nic Gillings et al. 50 citations

UNLABELLED: PET brain imaging of the serotonin 2A (5-hydroxytryptamine 2A, or 5-HT(2A)) receptor has been widely used in clinical studies, and currently, several well-validated radiolabeled antagonist tracers are used for in vivo imaging of the cerebral 5-HT(2A) receptor. Access to 5-HT(2A) receptor agonist PET tracers would, however, enable imaging of the active, high-affinity state of...

DOI: 10.2967/jnumed.109.074021 (opens in new tab) Full text (opens in new tab) Radioligand Agonist Receptor Radiosynthesis +2