Synapses, predictions, and prediction errors: A neocortical computational study of MDD using the temporal memory algorithm of HTM
Frontiers in Psychiatry February 23, 2023 Rammohan Shukla, Mohamed Sherif, Mostafa Z. Khalil et al. 1 citation
Introduction Synapses and spines play a significant role in major depressive disorder (MDD) pathophysiology, recently highlighted by the rapid antidepressant effect of ketamine and psilocybin. According to the Bayesian brain and interoception perspectives, MDD is formalized as being stuck in affective states constantly predicting negative energy balance. To understand how spines and synapses...