No evidence of immediate or persistent analgesic effect from a single dose of psilocybin in three mouse models of pain
Nature Communications January 22, 2026 Nicholas Gregory, Tyler E. Girard, Akila Ram et al. 5 citations
The psychedelic psilocybin may have lasting therapeutic effects for patients with chronic pain syndromes. Some preclinical data suggest these putative benefits derive from direct analgesic effects; however, this possibility has not been comprehensively tested in preclinical models. Here, we evaluated the analgesic properties of a single exposure to psilocybin at acute and chronic time points in...