Psilocybin inhibits formalin-induced nociception through 5-hydroxytryptamine 2A receptor in rats
Behavioural Pharmacology September 25, 2025 Saadet Inan, Paige E. Morris, Scott M. Rawls et al.
Psilocybin is found in a family of mushrooms commonly known as Psilocybe. We aimed to study the antinociceptive efficacy of psilocybin using formalin-induced noxious stimuli, a model that comprises both acute and persistent pain in rats. Adult male Sprague–Dawley rats were used. Psilocybin (0.1, 0.3, and 1 mg/kg, IP) or vehicle was administered, and 6 h later, formalin (5%, 50 µL, subcutaneous)...