The Journal of Nervous and Mental Disease
September 1, 2024
Valerio Ricci, Giuseppe Maina, Gilberto Di Petta et al.
The psychopathological manifestations associated with substance use, including induced psychotic experiences, are increasingly relevant but not well-understood within the medical community. Novel psychoactive substances and potentiated old compounds like cannabis and cocaine have emerged as a global concern, especially among adolescents and young adults. Transition rates from substance-induced...
Current Topics in Medicinal Chemistry
August 1, 2024
Valerio Ricci, Domenico de Berardis, Giovanni Martinotti et al.
Background: Cannabis is the most widely used illicit substance. Numerous scientific evidence confirm the strong association between cannabis and psychosis. Exposure to cannabis can induce the development of psychosis and schizophrenia in vulnerable individuals. However, the neurobiological processes underlying this relationship are unknown. Neurotrophins are a class of proteins that serve as...
Healthcare
January 29, 2024
Valerio Ricci, Domenico de Berardis, Giuseppe Maina
16 citations
This narrative review explores the efficacy and tolerability of third-generation antipsychotics (TGAs)-aripiprazole, cariprazine, brexpiprazole, and lurasidone-for the management of substance-induced psychosis (SIP). SIP is a psychiatric condition triggered by substance misuse or withdrawal, characterized by unique features distinct from those of primary psychotic disorders. These distinctive...
Frontiers in Psychiatry
January 8, 2024
Valerio Ricci, Ilenia di Muzio, Franca Ceci et al.
Background Natural Cannabis (NC) and Synthetic Cannabinoids (SCs) use can increase the risk and exacerbate the course of psychotic disorders. These could be influenced by the Aberrant Salience (AS) construct. It refers to an excess of attribution of meaning to stimuli that are otherwise regarded as neutral, thereby transform them into adverse, dangerous, or mysterious entities. This leads the...
Psychopathology
2024
Valerio Ricci, Giuseppe Maina, Giovanni Martinotti
11 citations
The term "dissociation" encompasses a wide array of symptoms and phenomena, all sharing the common characteristic of involving altered states of consciousness where an individual temporarily loses the sense of continuity of their own identity. In the context of addiction pathology, however, the dissociative paradigm remains a topic of ongoing debate. It fluctuates between the description of...
Psychopathology
2024
Valerio Ricci, Giuseppe Maina, Giovanni Martinotti
8 citations
The state of twilight consciousness is marked by a focused narrowing of awareness, maintaining vigilance and attention while simultaneously experiencing perceptual shifts in the surrounding environment. It is crucial to recognize that this twilight state represents not just a contraction but also an expansion of conscious experience. Substances of abuse, particularly new psychoactive...
EClinicalMedicine
September 8, 2023
Mathilde Argote, Guillaume Sescousse, Jérôme Brunelin et al.
31 citations
Background: The association between cannabis use and positive symptoms in schizophrenia spectrum disorders is well documented, especially via meta-analyses. Yet, findings are inconsistent regarding negative symptoms, while other dimensions such as disorganization, depression, and excitement, have not been investigated. In addition, meta-analyses use aggregated data discarding important...
International Journal of Environmental Research and Public Health
November 30, 2021
Valerio Ricci, Giovanni Martinotti, Franca Ceci et al.
33 citations
BACKGROUND: The Duration of Untreated Psychosis (DUP) is the time between the first-episode psychosis (FEP) and the initiation of antipsychotic treatment. It is an important predictor of several disease-related outcomes in psychotic disorders. The aim of this manuscript is investigating the influence of cannabis on the DUP and its clinical correlates. METHODS: During years 2014-2019, sixty-two...
Drug and Alcohol Dependence
October 1, 2021
Valerio Ricci, Franca Ceci, Francesco di Carlo et al.
BACKGROUND Cannabis is the most used recreational drug worldwide. Its use can increase the risk of developing psychotic disorders and exacerbate their course. However, the relationship between cannabis use and dissociative symptoms has been scarcely investigated. AIMS To examine differences in psychotic and dissociative symptoms, and in functioning in first-episode psychotic patients (FEPp)...
Addiction Biology
July 2010
Francesco Angelucci, Valerio Ricci, Giovanni Martinotti et al.
The recreational drug 'ecstasy'[3,4-methylenedioxymethamphetamine (MDMA)] exerts a potent action on central serotonergic and dopaminergic neurons. These neurons utilize neurotrophins for their survival and function. In order to explore MDMA effects on neurotrophins, we measured by enzyme-linked immunosorbent assay the serum levels of brain-derived neurotrophic factor (BDNF) and nerve growth...