Rapid, biochemical tagging of cellular activity history in vivo
Nature Methods August 5, 2024 Run Zhang, Maribel Anguiano, Sophia Lin et al. 20 citations
Abstract Intracellular calcium (Ca 2+ ) is ubiquitous to cell signaling across biology. While existing fluorescent sensors and reporters can detect activated cells with elevated Ca 2+ levels, these approaches require implants to deliver light to deep tissue, precluding their noninvasive use in freely behaving animals. Here we engineered an enzyme-catalyzed approach that rapidly and...