Metabolism and cytotoxicity studies of the two hallucinogens 1cP-LSD and 4-AcO-DET in human liver and zebrafish larvae models using LC-HRMS/MS and a high-content screening assay.
Journal of Pharmaceutical and Biomedical Analysis August 1, 2024 Tanja M Gampfer, Victoria Schütz, Philip Schippers et al. 11 citations
The continuous emergence of new psychoactive substances (NPS) attracted a great deal of attention within recent years. Lately, the two hallucinogenic NPS 1cP-LSD and 4-AcO-DET have appeared on the global market. Knowledge about their metabolism to identify potential metabolic targets for analysis and their cytotoxic properties is lacking. The aim of this work was thus to study their in vitro...
DOI: 10.1016/j.jpba.2024.116187 (opens in new tab)
Full text (opens in new tab)
Cytotoxicity
Hepg2
Lc-hrms/ms
New psychoactive substances
+5