Serotonergic psychedelics and amphetamine shift male rat ultrasonic vocalizations toward call patterns associated with positively valenced states.
Progress in Neuro-Psychopharmacology and Biological Psychiatry September 18, 2026 Ewelina Cyrano, Joanna Gołębiowska, Piotr Popik et al.
Psychedelics and psychostimulants produce subjective and often positive affective effects in humans. In rats, positive affective states are often associated with frequency-modulated ultrasonic vocalizations (USVs). We examined whether the hallucinogenic 2,5-dimethoxy-4-iodoamphetamine (DOI; 1.25-2.5 mg/kg) and LSD (0.04-0.08 mg/kg), the non-hallucinogenic lisuride (0.03 or 0.3 mg/kg) and the...
DOI: 10.1016/j.pnpbp.2026.111940 (opens in new tab)
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Affective vocalization
Behavioral phenotyping
Machine learning
Rodent