Ewelina Cyrano

2 papers in the library · publishing 2024-2026

Papers

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Serotonergic psychedelics and amphetamine shift male rat ultrasonic vocalizations toward call patterns associated with positively valenced states.

Progress in Neuro-Psychopharmacology and Biological Psychiatry September 18, 2026 Ewelina Cyrano, Joanna Gołębiowska, Piotr Popik et al.

Psychedelics and psychostimulants produce subjective and often positive affective effects in humans. In rats, positive affective states are often associated with frequency-modulated ultrasonic vocalizations (USVs). We examined whether the hallucinogenic 2,5-dimethoxy-4-iodoamphetamine (DOI; 1.25-2.5 mg/kg) and LSD (0.04-0.08 mg/kg), the non-hallucinogenic lisuride (0.03 or 0.3 mg/kg) and the...

DOI: 10.1016/j.pnpbp.2026.111940 Full text Affective vocalization Behavioral phenotyping Machine learning Rodent

Assessing the effects of 5-HT2A and 5-HT5A receptor antagonists on DOI-induced head-twitch response in male rats using marker-less deep learning algorithms

Pharmacological Reports November 27, 2024 Ewelina Cyrano, Piotr Popik

Serotonergic psychedelics, which display a high affinity and specificity for 5-HT2A receptors like 2,5-dimethoxy-4-iodoamphetamine (DOI), reliably induce a head-twitch response in rodents characterized by paroxysmal, high-frequency head rotations. Traditionally, this behavior is manually counted by a trained observer. Although automation could simplify and facilitate data collection, current...

DOI: 10.1007/s43440-024-00679-1 Full text