Alex James Major

Propofol-mediated loss of consciousness disrupts predictive routing and local field phase modulation of neural activity.

Proceedings of the National Academy of Sciences October 15, 2024 Yihan Sophy Xiong, Jacob Donoghue, Mikael Lundqvist et al. 32 citations

Predictive coding is a fundamental function of the cortex. The predictive routing model proposes a neurophysiological implementation for predictive coding. Predictions are fed back from the deep-layer cortex via alpha/beta (8 to 30 Hz) oscillations. They inhibit the gamma (40 to 100 Hz) and spiking that feed sensory inputs forward. Unpredicted inputs arrive in circuits unprepared by alpha/beta,...