Single administration of a psychedelic [(R)-DOI] influences coping strategies to an escapable social stress.
Neuropharmacology July 1, 2024 Kevin T Krupp, Jazmine D W Yaeger, Leighton J Ledesma et al. 11 citations
Psychedelic compounds have potentially rapid, long-lasting anxiolytic, antidepressive and anti-inflammatory effects. We investigated whether the psychedelic compound (R)-2,5-dimethoxy-4-iodoamphetamine [(R)-DOI], a selective 5-HT2A receptor partial agonist, decreases stress-related behavior in male mice exposed to repeated social aggression. Additionally, we explored the likelihood that these...