Isolation of psychedelic-responsive neurons underlying anxiolytic behavioral states.
Science (New York, N.Y.) November 15, 2024 Jessie Muir, S Lin, Isak K Aarrestad et al. 37 citations
Psychedelics hold promise as alternate treatments for neuropsychiatric disorders. However, the neural mechanisms by which they drive adaptive behavioral effects remain unclear. We isolated the specific neurons modulated by a psychedelic to determine their role in driving behavior. Using a light- and calcium-dependent activity integrator, we genetically tagged psychedelic-responsive neurons in...