Opioids cause dissociated states of consciousness in C57BL/6J mice.
Journal of Neurophysiology October 1, 2021 Christopher B O'Brien, Clarence E Locklear, Zachary T Glovak et al. 18 citations
The electroencephalogram (EEG) provides an objective, neural correlate of consciousness. Opioid receptors modulate mammalian neuronal excitability, and this fact was used to characterize how opioids administered to mice alter EEG power and states of consciousness. The present study tested the hypothesis that antinociceptive doses of fentanyl, morphine, or buprenorphine differentially alter the...