Marta Cano

2 papers in the library · 5 citations · publishing 2024-2026

Papers

Mindfulness-based cognitive therapy neurobiology in treatment-resistant obsessive-compulsive disorder: A domain-related resting-state networks approach.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology May 1, 2024 Víctor De la Peña-arteaga, Marta Cano, Daniel Porta-Casteràs et al. 5 citations

In patients with obsessive-compulsive disorder (OCD) undergoing a 3-month mindfulness-based cognitive therapy (MBCT) programme, distinct baseline brain connectivity patterns were associated with four clinical domains: positive affect, negative affect, anxiety sensitivity, and rumination. Key brain nodes—the precuneus and frontopolar cortex—within the ventral default mode network and frontostriatal network showed predictive and response associations with clinical changes. MBCT may modulate connectivity in these networks, potentially reducing symptoms across domains. These network-based biomarkers could help personalize treatment and identify patients most likely to benefit from MBCT.

DOI: 10.1016/j.euroneuro.2024.02.011 Full text Brain connectivity Mindfulness-based interventions Neurobiology Neuroimaging +1

Clinical and Neuroimaging Effects of Mindfulness-Based Cognitive Therapy for Symptomatic Obsessive-Compulsive Disorder Patients after First-Line Treatments: A Randomised Controlled Trial.

Psychotherapy and Psychosomatics January 1, 2026 Maria Serra-Blasco, Neus Miquel-Giner, Muriel Vicent-Gil et al.

Mindfulness-based cognitive therapy (MBCT) added to usual treatment reduces obsessive-compulsive disorder (OCD) symptoms more than usual treatment alone. In a trial of 68 moderately symptomatic adults, those receiving MBCT showed a 31.73% reduction on the Yale-Brown Obsessive-Compulsive Scale compared to 8.07% in the treatment-as-usual group. MBCT also lowered depressive symptoms, rumination, and perceived stress, and improved quality of life. No changes in resting-state brain connectivity were detected after treatment, but lower baseline connectivity in fronto-striatal, salience, and default mode networks predicted greater symptom reduction, suggesting a neural basis for MBCT response.

DOI: 10.1159/000548961 Full text Combined modality therapy Mindfulness-based cognitive therapy Neural pathways Obsessive-compulsive disorder +1