A Phase 1 single ascending dose study of pure oral harmine in healthy volunteers.
Journal of psychopharmacology (Oxford, England) October 1, 2024 Jessica L Ables, Leah Israel, Olivia Wood et al. 17 citations
Harmine is a component of the hallucinogenic brew, Ayahuasca, which also contains the psychoactive compound, N, N-dimethyltryptamine. Whether pharmaceutical-grade harmine hydrochloride (HCl) has psychoactive effects, the doses at which these might occur, and the dose-response relationship to side effects and safety in humans are unknown. We conducted a Phase 1, open-label single ascending dose...