Mechanism of antidepressant action of ketamine and differences between its two enantiomers.
Journal of Anesthesia and Translational Medicine September 1, 2025 Junbiao Zhan, Yuxi Zhang, Hao Tian et al.
Ketamine has been widely used since its discovery, and in addition to its anesthetic effects, in recent years it has been found to exhibit rapid and sustained antidepressant effects in rodent models and in patients with treatment-resistant depression (TRD) at subanesthetic doses. The antidepressant mechanism of ketamine has also been intensively studied, involving glutamate receptors such as...