Slow and fast cortical cholinergic arousal is reduced in a mouse model of focal seizures with impaired consciousness.
Cell Reports December 24, 2024 Lim-Anna Sieu, Shobhit Singla, Jiayang Liu et al. 8 citations
Patients with focal temporal lobe seizures often experience loss of consciousness associated with cortical slow waves, like those in deep sleep. Previous work in rat models suggests that decreased subcortical arousal causes depressed cortical function during focal seizures. However, these studies were performed under light anesthesia, making it impossible to correlate conscious behavior with...