medRxiv
August 31, 2026
Jonathan Huntley, Benjy Barnett, Daniel Bor et al.
preprint
Despite extensive knowledge of the progressive sequence of cognitive and functional deficits in Alzheimer's Disease (AD), the impact of neurodegeneration on the conscious experience of patients remains largely unexplored. Understanding how the content of consciousness, particularly perceptual awareness, changes with the progression of AD is crucial to enable meaningful person-centred care. This...
Nature Mental Health
June 1, 2026
George E. Chapman, Philip R. Corlett, Stephen M Fleming et al.
Delusions are a key feature of psychotic disorders, yet their fixity remains underexplored. Here, the authors propose a refined vocabulary for delusion fixity, review influencing factors, and present a working model. The Review calls for interdisciplinary longitudinal studies that could enhance the understanding of delusion fixity and facilitate the advancement of therapeutic strategies. Fixed,...
Ageing Research Reviews
May 1, 2025
Beatriz Pozuelo Moyano, Denise Gomez Bautista, Karla Jocelyn Porras Ibarra et al.
12 citations
Treatment-resistant late-life depression (TRLLD) affects nearly half of older adults with major depression. This systematic review evaluates published evidence of effectiveness of both pharmacological and non-pharmacological treatments for TRLLD. A search of MEDLINE, EMBASE, CINAHL, PsycINFO, the Cochrane Library, and online trial registries up to March 2024 was conducted to identify randomized...
Frontiers in Human Neuroscience
February 1, 2023
Jonathan Huntley, Daniel Bor, Feng Deng et al.
There is an urgent need to understand the nature of awareness in people with severe Alzheimer's disease (AD) to ensure effective person-centered care. Objective biomarkers of awareness validated in other clinical groups (e.g., anesthesia, minimally conscious states) offer an opportunity to investigate awareness in people with severe AD. In this article we demonstrate the feasibility of using...
Alzheimer's & Dementia
2021
Jonathan Huntley, Stephen M Fleming, Daniel C Mograbi et al.
People with Alzheimer's disease (AD) demonstrate a range of alterations in consciousness. Changes in awareness of cognitive deficit, self-awareness, and introspection are seen early in AD, and dysfunction of awareness and arousal progresses with increasing disease severity. However, heterogeneity of deficits between individuals and a lack of empirical studies in people with severe dementia...