Esketamine ameliorates depression-like behavior in mice via modulation of the NRG1-ErbB4 pathway.
Frontiers in Psychiatry 2026 Hang Yu, Yuqiong Zhu, Jie Wang et al.
Esketamine has a significant and rapid antidepressant effect. Although studies have shown that Neuregulin 1 (NRG1) and it's signaling pathway are associated with depression, the possible regulatory relationship of esketamine on the NRG1-ErbB4 pathway is not yet clear. To induce depressive-like behavior in mice, a Chronic Social Defeat Stress (CSDS) model was established. Behavioral indicators...