Ibogaine possesses a selective affinity for sigma 2 receptors.
Life Sciences 1995 R H Mach, C R Smith, S R Childers 145 citations
The alkaloid ibogaine is potentially useful to reduce craving for several drugs of abuse, but its mechanism of action is not known. In the current study, in vitro studies were conducted in order to determine the affinity of ibogaine for sigma receptors. Our results indicate that ibogaine has a relatively high affinity for sigma 2 receptors (Ki = 90.4 and 250 nM) and a significantly lower...