Effects of ibogaine, and cocaine and morphine after ibogaine, on ventral tegmental dopamine neurons.
Life Sciences 1996 E D French, K Dillon, S F Ali 12 citations
Ibogaine, an indole containing alkaloid, has been shown to reduce the rate of injection of morphine and cocaine in self-administration protocols. Since morphine- and cocaine-induced modulation of dopamine release is impulse dependent and essential for their reinforcing effects, disruption of dopamine neuronal activity by ibogaine could explain its purported 'antiaddictive' properties....