Neuropharmacological characterization of local ibogaine effects on dopamine release.
Journal of neural transmission (Vienna, Austria : 1996) 1996 M S Reid, K Hsu, K H Souza et al. 19 citations
Local perfusion with ibogaine (10(-6) M-10(-3) M) via microdialysis probes in the nucleus accumbens or striatum of rats produced a biphasic dose-response effect on extracellular dopamine levels. Lower doses (10(-6) M-10(-4) M) produced a decrease while higher doses (5 x 10(-4) M-10(-3) M) produced an increase in dopamine levels. Dihydroxyphenylacetic acid (DOPAC) levels were not effected....