Claudio A Villalobos

2 papers in the library · 50 citations · publishing 2002-2004

Papers

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4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes.

British Journal of Pharmacology April 1, 2004 Claudio A Villalobos, Paulina Bull, Patricio Sáez et al. 50 citations

1. We recently described that several 2-(2,5-dimethoxy-4-substituted phenyl)ethylamines (PEAs), including 4-I=2C-I, 4-Br=2C-B, and 4-CH(3)=2C-D analogs, are partial agonists at 5-HT(2C) receptors, and show low or even negligible intrinsic efficacy at 5-HT(2A) receptors. These results raised the proposal that these drugs may act as 5-HT(2) antagonists. 2. To test this hypothesis, Xenopus laevis...

DOI: 10.1038/sj.bjp.0705722 Full text 5-ht2a receptor Psychoactive compounds Psychoactive effects Phenylethylamines +5

Differences in potency and efficacy of a series of phenylisopropylamine/phenylethylamine pairs at 5-HT(2A) and 5-HT(2C) receptors.

British Journal of Pharmacology June 1, 2002 Claudio Acuña-Castillo, Claudio A Villalobos, Pablo R Moya et al.

The pharmacological profile of a series of (+/-)-2,5-dimethoxy-4-(X)-phenylisopropylamines (X=I, Br, NO(2), CH(3), or H) and corresponding phenylethylamines, was determined in Xenopus laevis oocytes injected with cRNA coding for rat 5-HT(2A) or 5-HT(2C) receptors. The efficacy and relative potency of these drugs were determined and compared to classical 5-HT(2) receptor agonists and...

DOI: 10.1038/sj.bjp.0704747 Full text