Effects of salvinorin A, a kappa-opioid hallucinogen, on a neuroendocrine biomarker assay in nonhuman primates with high kappa-receptor homology to humans.
Journal of Pharmacology and Experimental Therapeutics 2007 Eduardo R Butelman, Marek Mandau, Kevin Tidgewell et al. 64 citations
This study focused on the in vivo effects of the kappa-opioid hallucinogen salvinorin A, derived from the plant Salvia divinorum. The effects of salvinorin A (0.0032-0.056 mg/kg i.v.) were studied in a neuroendocrine biomarker assay of the anterior pituitary hormone prolactin in gonadally intact, adult male and female rhesus monkeys (n = 4 each). Salvinorin A produced dose- and time-dependent...
DOI: 10.1124/jpet.106.112417 (opens in new tab)
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Plant-derived compound
Hallucinogen
Kappa-opioid agonist
Opioid antagonist
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