The hallucinogen derived from Salvia divinorum, salvinorin A, has kappa-opioid agonist discriminative stimulus effects in rats.
Neuropharmacology September 1, 2007 Catherine B Willmore-Fordham, Daniel M Krall, Christopher R Mccurdy et al. 49 citations
Data from clinical and preclinical studies converge implicating the plant-derived hallucinogen salvinorin A as an important pharmacologic tool; this psychoactive compound may expand scientific understandings on mammalian kappa-opioid receptor systems. Human salvinorin A effects, consistent with kappa-opioid receptor agonism, include antinociception, sedation, dysphoria and distorted...
DOI: 10.1016/j.neuropharm.2007.06.008 (opens in new tab)
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Neuroscience: brain chemistry
Brain receptors
Perception
Mood regulation
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