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Mimi Pham

2 papers in the library · 113 citations · publishing 2011-2013

Papers

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Unique and potent effects of acute ibogaine on zebrafish: the developing utility of novel aquatic models for hallucinogenic drug research.

Behavioural Brain Research 2013 Jonathan Cachat, Evan J. Kyzar, Christopher Collins et al. 112 citations

An indole alkaloid, ibogaine is the principal psychoactive component of the iboga plant, used by indigenous peoples in West Africa for centuries. Modulating multiple neurotransmitter systems, the drug is a potent hallucinogen in humans, although its psychotropic effects remain poorly understood. Expanding the range of model species is an important strategy for translational neuroscience...

DOI: 10.1016/j.bbr.2012.08.041 (opens in new tab) Full text (opens in new tab) Zebrafish model Zebrafish research Animal model Aquatic model +31

3D‐based analyses of pharmacological modulation of zebrafish locomotion

The FASEB Journal April 1, 2011 Jonathan Cachat, Russell Reihl, Jessica Cosgrove et al. 1 citation

Here, we integrated manual observations, computerized event‐based scoring and automated video analysis of zebrafish traces to generate three‐dimensional (3D) swim path reconstruction of general behavioral patterns, thereby improving the characterization and interpretation of complex, anxiety‐related adult zebrafish behavior. Drugs known to evoke a high‐anxiety state (caffeine, repeated morphine...